Thursday, January 31, 2013

Lokpal Bill: Union Cabinet to mull over key changes




Union Cabinet clears ‘revised’ Lokpal Bill Zeenews Bureau

New Delhi: The Union Cabinet on Thursday approved the key recommendations made by the Select Committee of the Rajya Sabha to the Lokpal Bill.

Confirming the development, Union Minister of State in PMO V Narayanasamy said, ?Today the Union Cabinet accepted 14 out of 16 recommendations made by the Select Committee of the Rajya Sabha. The revised Lokpal Bill draft will now be introduced to the Rajya Sabha for vote.?

Addressing a joint press briefing with I&B Minister Manish Tewari, Narayanasamy said, ?The revised bill incorporates a number of changes recommended by the Rajya Sabha Select Committee, including appointment of the Director of Prosecution by the CVC.?

?The amended Lokpal bill will make it mandatory for the states to set up their own lokayuktas, or anti-corruption ombudsmen, within a year of the bill coming into effect,? he said.

After the recommendations, political parties will be brought under the ambit of the Lokpal. ?Religious and charitable institutions, including non-governmental organisations partially aided by the government, will be exempted,? he added.

The minister agreed that despite accepting major recommendations of the select panel, differences remain on several issues.

?The government has disagreed with the select committee's view that the power to transfer CBI officials should rest with the Lokpal and not the investigative agency,? Narayanasamy said.

The government also doesn't favour the committee's recommendation that officials facing an inquiry from the Lokpal should not be heard during the preliminary stage of the probe.

Union Cabinet clears ‘revised’ Lokpal Bill

On the issue of giving opportunity to an official to present his or her view, the government feels that a protection is required for such a person and depriving the officials facing allegations the opportunity to present their views will be against the "principle of protection,? he said.

The Centre also agreed to a proposal of the Department of Personnel (DoPT) over the appointment of the CBI chief by an independent collegium comprising the Prime Minister, Leader of the Opposition in the Lok Sabha and the Chief Justice of India.

The Select Committee was formed to look into the recommendations of the Rajya Sabha members for the Lokpall Bill.

UPA chairperson Sonia Gandhi recently gave an assurance to anti-corruption crusader Anna Hazare that the Lokpal Bill will be passed in the upcoming Budget Session.

Union Cabinet clears ‘revised’ Lokpal Bill

Sonia's assurance came two days before Anna Hazare began his nationwide tour for strengthening the organisation of farmers.

The Lokpal Bill was passed in the Lok Sabha in December 2011, but could not be put to vote in the Rajya Sabha due to shortage of time. Since then the government has not brought the Lokpal Bill to Parliament.

The bill has already been passed by the Lok Sabha but the government's efforts to provide Lokpal with Constitutional status did not succeed in the Lower House.

With PTI Inputs

Source: http://zeenews.india.com/news/nation/lokpal-bill-union-cabinet-to-mull-over-key-changes_826059.html

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Wednesday, January 30, 2013

The FEBS-EMBO 2014 Conference

The FEBSEMBO 2014 Conference [ Back to EurekAlert! ] Public release date: 30-Jan-2013
[ | E-mail | Share Share ]

Contact: Barry Whyte
communications@embo.org
49-622-188-91108
European Molecular Biology Organization

30 January 2013 The Federation of European Biochemical Societies (FEBS), EMBO, and the French Society for Biochemistry and Molecular Biology will hold a joint conference for the life sciences in 2014. The FEBSEMBO 2014 Conference will take place from the 30 August to 4 September at the Palais des Congrs in Paris, France.

The FEBSEMBO 2014 Conference will be a unique international event that brings together many leading researchers to discuss the latest scientific findings in the life sciences. Scientists from across the world will be able to attend a jointly organized conference that offers unparalleled scope for the entire range of the molecular life sciences. The conference will also celebrate the 50th anniversaries of FEBS and EMBO and the 100th anniversary of the French Society for Biochemistry and Molecular Biology.

Israel Pecht, Secretary General of FEBS, commented: "It gives me great pleasure to welcome EMBO and the French Society for Biochemistry and Molecular Biology as partners for this life sciences conference that will take place in 2014. I believe the strengths of each organization will contribute to an outstanding event for all life scientists. It will also be an ideal opportunity to celebrate the achievements of all three organizations over the past decades."

Maria Leptin, Director of EMBO, remarked: "High-calibre conferences where scientists of all ages have access to the very best speakers are an essential part of building a research community. Our partnership with FEBS and the French Society for Biochemistry and Molecular Biology for The FEBSEMBO 2014 Conference will help to increase the impact of our efforts to create a research environment where scientists can achieve their best work."

Frdric Dardel, President of the French Society for Biochemistry and Molecular Biology, added: "It is a privilege and an honour to be holding this special event for the life sciences in France and I look forward to welcoming the scientific community to Paris next year. We have the perfect partners and venue for this prestigious occasion."

###

Further information about the joint conference will be made available at the 38th FEBS Congress in St Petersburg, Russia (6-11 July 2013) and The 5th EMBO Meeting in Amsterdam, The Netherlands (21-24 September 2013).

About EMBO

EMBO is an organization of more than 1500 leading researchers that promotes excellence in the life sciences. The major goals of the organization are to support talented researchers at all stages of their careers, stimulate the exchange of scientific information, and help build a European research environment where scientists can achieve their best work. For more information: www.embo.org

About FEBS

Founded in 1964, The Federation of European Biochemical Societies (FEBS) is one of the largest organizations in European life sciences, with nearly 40,000 members distributed among 43 countries across the continent and its immediate neighbours. As a charitable organization, FEBS promotes and supports the molecular life sciences in various ways from offering advanced courses and different types of research fellowships to publishing journals. For more information: www.febs.org

About The French Society for Biochemistry and Molecular Biology

The French Society for Biochemistry and Molecular Biology develops and promotes Biochemistry and Molecular Biology in research and teaching, both in universities and centers of research as well as industry. Members of the organization are involved in learned societies devoted to biochemistry at the international level. The French Society for Biochemistry and Molecular Biology, which was founded in 1914, has been a member of FEBS since 1964. For more information: www.sfbbm.fr

Contact EMBO

Barry Whyte
Head, EMBO Public Relations & Communications
Phone + 49 (0) 6221 8891 108
communications@embo.org

Contact FEBS

Professor Israel Pecht, FEBS Secretary General
Department of Immunology,
The Weizmann Institute of Science
76100 Rehovot, Israel
Tel: +972 8 9344020
Fax: +972 8 9465264
israel.pecht@weizmann.ac.il

Carolyn Elliss, FEBS Communications Officer
FEBS Treasury
98 Regent Street
Cambridge CB2 1DP
United Kingdom
elliss@febs.org

Contact The French Society for Biochemistry and Molecular Biology

Xavier Coumoul
INSERM UMR-S 747,
Universit Paris Descartes
45 rue des Saints-Pres
75006 Paris France
Tel: +33 1 42 86 33 59
Fax: +33 1 42 86 38 68
xavier.coumoul@parisdescartes.fr



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


The FEBSEMBO 2014 Conference [ Back to EurekAlert! ] Public release date: 30-Jan-2013
[ | E-mail | Share Share ]

Contact: Barry Whyte
communications@embo.org
49-622-188-91108
European Molecular Biology Organization

30 January 2013 The Federation of European Biochemical Societies (FEBS), EMBO, and the French Society for Biochemistry and Molecular Biology will hold a joint conference for the life sciences in 2014. The FEBSEMBO 2014 Conference will take place from the 30 August to 4 September at the Palais des Congrs in Paris, France.

The FEBSEMBO 2014 Conference will be a unique international event that brings together many leading researchers to discuss the latest scientific findings in the life sciences. Scientists from across the world will be able to attend a jointly organized conference that offers unparalleled scope for the entire range of the molecular life sciences. The conference will also celebrate the 50th anniversaries of FEBS and EMBO and the 100th anniversary of the French Society for Biochemistry and Molecular Biology.

Israel Pecht, Secretary General of FEBS, commented: "It gives me great pleasure to welcome EMBO and the French Society for Biochemistry and Molecular Biology as partners for this life sciences conference that will take place in 2014. I believe the strengths of each organization will contribute to an outstanding event for all life scientists. It will also be an ideal opportunity to celebrate the achievements of all three organizations over the past decades."

Maria Leptin, Director of EMBO, remarked: "High-calibre conferences where scientists of all ages have access to the very best speakers are an essential part of building a research community. Our partnership with FEBS and the French Society for Biochemistry and Molecular Biology for The FEBSEMBO 2014 Conference will help to increase the impact of our efforts to create a research environment where scientists can achieve their best work."

Frdric Dardel, President of the French Society for Biochemistry and Molecular Biology, added: "It is a privilege and an honour to be holding this special event for the life sciences in France and I look forward to welcoming the scientific community to Paris next year. We have the perfect partners and venue for this prestigious occasion."

###

Further information about the joint conference will be made available at the 38th FEBS Congress in St Petersburg, Russia (6-11 July 2013) and The 5th EMBO Meeting in Amsterdam, The Netherlands (21-24 September 2013).

About EMBO

EMBO is an organization of more than 1500 leading researchers that promotes excellence in the life sciences. The major goals of the organization are to support talented researchers at all stages of their careers, stimulate the exchange of scientific information, and help build a European research environment where scientists can achieve their best work. For more information: www.embo.org

About FEBS

Founded in 1964, The Federation of European Biochemical Societies (FEBS) is one of the largest organizations in European life sciences, with nearly 40,000 members distributed among 43 countries across the continent and its immediate neighbours. As a charitable organization, FEBS promotes and supports the molecular life sciences in various ways from offering advanced courses and different types of research fellowships to publishing journals. For more information: www.febs.org

About The French Society for Biochemistry and Molecular Biology

The French Society for Biochemistry and Molecular Biology develops and promotes Biochemistry and Molecular Biology in research and teaching, both in universities and centers of research as well as industry. Members of the organization are involved in learned societies devoted to biochemistry at the international level. The French Society for Biochemistry and Molecular Biology, which was founded in 1914, has been a member of FEBS since 1964. For more information: www.sfbbm.fr

Contact EMBO

Barry Whyte
Head, EMBO Public Relations & Communications
Phone + 49 (0) 6221 8891 108
communications@embo.org

Contact FEBS

Professor Israel Pecht, FEBS Secretary General
Department of Immunology,
The Weizmann Institute of Science
76100 Rehovot, Israel
Tel: +972 8 9344020
Fax: +972 8 9465264
israel.pecht@weizmann.ac.il

Carolyn Elliss, FEBS Communications Officer
FEBS Treasury
98 Regent Street
Cambridge CB2 1DP
United Kingdom
elliss@febs.org

Contact The French Society for Biochemistry and Molecular Biology

Xavier Coumoul
INSERM UMR-S 747,
Universit Paris Descartes
45 rue des Saints-Pres
75006 Paris France
Tel: +33 1 42 86 33 59
Fax: +33 1 42 86 38 68
xavier.coumoul@parisdescartes.fr



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-01/embo-tf2013013.php

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U.S. struggles over which gun crimes to prosecute

WASHINGTON (Reuters) - A dispute erupted at a congressional hearing on Wednesday over which existing gun-control laws were worth enforcing, even as lawmakers debated whether to pass new ones.

The flashes of anger underscored the deep divisions in America's gun culture.

"You do not support background checks for all buyers of firearms?" Democratic Senator Patrick Leahy of Vermont asked the head of the National Rifle Association, the largest U.S. gun rights lobby.

NRA Chief Executive Wayne LaPierre said he did not support checking all buyers when President Barack Obama's administration was failing to enforce existing gun laws that, for example, prohibit lying on a background-check form.

"This administration is not prosecuting the people that they catch," LaPierre fired back during a hearing of the Senate Judiciary Committee, where Leahy, the chairman, began what promises to be a long congressional fight over gun control.

Obama proposed tougher guidelines after 20-year-old gunman Adam Lanza killed his mother and then six adults and 20 students at a Newtown, Connecticut, elementary school last month before turning a gun on himself.

Obama's Justice Department has shown little appetite to prosecute what it considers low-level firearms crimes at the expense of time spent on sweeping investigations, officials with the department said.

Investigators are also working under the shadow of a botched gun probe known as "Operation Fast and Furious," an investigation into gun trafficking along the U.S.-Mexico border that developed into a political scandal in Obama's first term.

'PAPERWORK' CRIME

Thousands of potential federal gun crimes go unprosecuted each year, the result of efforts by the Justice Department and the U.S. Bureau of Alcohol, Tobacco, Firearms and Explosives, or ATF, to determine which ones are most important, according to studies funded by the department.

The most common lead that agents pass up is a "paperwork" crime.

In those instances, someone with a criminal conviction or other disqualifying factor tries to buy a gun but does not disclose his past, either because he lied or forgot to do so. A background check finds him ineligible and bars him from getting a firearm, but he can be prosecuted for trying.

Some of those attempted buyers are otherwise law-abiding citizens who should not be a priority, said Michael Bouchard, a former ATF assistant director for field operations.

"It's simply a matter of using your resources wisely to effectively combat violent crime," he said in an interview. "To combat violent crime, they're going to go after criminals who are already in possession of guns or are using guns, rather than people who didn't get a gun."

The FBI said it conducted 16.5 million background checks for gun purchases in 2011. Of those, 78,211 ended in denials of eligibility because of a past conviction, a warrant for an arrest, drug abuse or other reason. Forty-four attempted buyers faced prosecution in 2010.

PROSECUTIONS DROP

Federal prosecutors said they brought gun charges against 11,811 people in 2011, down 10 percent from their peak in 2005 when violent crime rates were higher and President George W. Bush's administration put more of an emphasis on certain gun crimes.

The National Rifle Association has repeatedly cited the drop in prosecutions as it pushes back against proposed new laws. At Wednesday's hearing, Republicans picked up on the theme.

"I hope we'll have a hearing where we'll ask administration witnesses to come before the panel and to testify why the Department of Justice and other law enforcement agencies of the federal government are not enforcing the laws that Congress has already passed," said Republican Senator John Cornyn of Texas.

Obama administration officials argue that not all gun offenses are worthy of the same attention.

Government investigators have "focused greater efforts on complex firearms investigations over the past several years in an effort to have the greatest impact on violent gun crime," said a Justice Department official, who spoke on condition of anonymity.

"While this may have resulted in fewer multiple-defendant cases, it has been beneficial for our overall public safety efforts," the official said.

Obama's own set of proposals on January 16 underscored the sensitivity surrounding what gun crimes get prosecuted. Rather than ordering the 94 U.S. Attorney's Offices to devote more resources to the subject, he simply asked those offices "to consider whether supplemental efforts would be appropriate in their districts."

Obama's proposals to curb gun violence include reinstating the U.S. ban on some semi-automatic rifles, limiting the capacity of ammunition magazines, and more extensive background checks of prospective gun buyers, largely to verify whether they have a history of crime or mental illness.

(Editing by Howard Goller and Peter Cooney)

Source: http://news.yahoo.com/u-struggles-over-gun-crimes-prosecute-001356647.html

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Casey Anthony Photo: Relaxing on the Beach, Looking For Closure

Source: http://www.thehollywoodgossip.com/2013/01/casey-anthony-photo-relaxing-on-the-beach-looking-for-closure/

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Researchers break million-core supercomputer barrier

Tuesday, January 29, 2013

Stanford Engineering's Center for Turbulence Research (CTR) has set a new record in computational science by successfully using a supercomputer with more than one million computing cores to solve a complex fluid dynamics problem?the prediction of noise generated by a supersonic jet engine.

Joseph Nichols, a research associate in the center, worked on the newly installed Sequoia IBM Bluegene/Q system at Lawrence Livermore National Laboratories (LLNL) funded by the Advanced Simulation and Computing (ASC) Program of the National Nuclear Security Administration (NNSA). Sequoia once topped list of the world's most powerful supercomputers, boasting 1,572,864 compute cores (processors) and 1.6 petabytes of memory connected by a high-speed five-dimensional torus interconnect.

Because of Sequoia's impressive numbers of cores, Nichols was able to show for the first time that million-core fluid dynamics simulations are possible?and also to contribute to research aimed at designing quieter aircraft engines.

THE PHYSICS OF NOISE

The exhausts of high-performance aircraft at takeoff and landing are among the most powerful human-made sources of noise. For ground crews, even for those wearing the most advanced hearing protection available, this creates an acoustically hazardous environment. To the communities surrounding airports, such noise is a major annoyance and a drag on property values.

Understandably, engineers are keen to design new and better aircraft engines that are quieter than their predecessors. New nozzle shapes, for instance, can reduce jet noise at its source, resulting in quieter aircraft.

Predictive simulations?advanced computer models?aid in such designs. These complex simulations allow scientists to peer inside and measure processes occurring within the harsh exhaust environment that is otherwise inaccessible to experimental equipment. The data gleaned from these simulations are driving computation-based scientific discovery as researchers uncover the physics of noise.

MORE CORES, MORE CHALLENGES

"Computational fluid dynamics (CFD) simulations, like the one Nichols solved, are incredibly complex. Only recently, with the advent of massive supercomputers boasting hundreds of thousands of computing cores, have engineers been able to model jet engines and the noise they produce with accuracy and speed," said Parviz Moin, the Franklin M. and Caroline P. Johnson Professor in the School of Engineering and Director of CTR.

CFD simulations test all aspects of a supercomputer. The waves propagating throughout the simulation require a carefully orchestrated balance between computation, memory and communication. Supercomputers like Sequoia divvy up the complex math into smaller parts so they can be computed simultaneously. The more cores you have, the faster and more complex the calculations can be.

And yet, despite the additional computing horsepower, the difficulty of the calculations only becomes more challenging with more cores. At the one-million-core level, previously innocuous parts of the computer code can suddenly become bottlenecks.

IRONING OUT THE WRINKLES

Over the past few weeks, Stanford researchers and LLNL computing staff have been working closely to iron out these last few wrinkles. This week, they were glued to their terminals during the first "full-system scaling" to see whether initial runs would achieve stable run-time performance. They watched eagerly as the first CFD simulation passed through initialization then thrilled as the code performance continued to scale up to and beyond the all-important one-million-core threshold, and as the time-to-solution declined dramatically.

"These runs represent at least an order-of-magnitude increase in computational power over the largest simulations performed at the Center for Turbulence Research previously," said Nichols "The implications for predictive science are mind-boggling."

A HOMECOMING

The current simulations were a homecoming of sorts for Nichols. He was inspired to pursue a career in supercomputing as a high-school student when he attended a two-week summer program at Lawrence Livermore computing facility in 1994 sponsored by the Department of Energy. Back then he worked on the Cray Y-MP, one of the fastest supercomputers of its time.

"Sequoia is approximately 10 million times more powerful than that machine," Nichols noted.

The Stanford ties go deeper still. The computer code used in this study is named CharLES and was developed by former Stanford senior research associate, Frank Ham. This code utilizes unstructured meshes to simulate turbulent flow in the presence of complicated geometry.

In addition to jet noise simulations, Stanford researchers in the Predictive Science Academic Alliance Program (PSAAP), sponsored by the Department of Energy, are using the CharLES code to investigate advanced-concept scramjet propulsion systems used in hypersonic flight (with video)?flight at many times the speed of sound?and to simulate the turbulent flow over an entire airplane wing.

###

Stanford School of Engineering: http://soe.stanford.edu

Thanks to Stanford School of Engineering for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126495/Researchers_break_million_core_supercomputer_barrier

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Tuesday, January 29, 2013

THE RESET: Bernanke keeping foot on stimulus pedal

FILE-In this Thursday, Sept. 13, 2012, file photo, Federal Reserve Chairman Ben Bernanke speaks during a news conference in Washington. First appointed by President George W. Bush in 2006 and given a second four-year term as chairman by President Barack Obama, Bernanke has not signaled whether he'd like a third four-year term as head of the nation's central bank if Obama pressed him to stay on. (AP Photo/Manuel Balce Ceneta, File)

FILE-In this Thursday, Sept. 13, 2012, file photo, Federal Reserve Chairman Ben Bernanke speaks during a news conference in Washington. First appointed by President George W. Bush in 2006 and given a second four-year term as chairman by President Barack Obama, Bernanke has not signaled whether he'd like a third four-year term as head of the nation's central bank if Obama pressed him to stay on. (AP Photo/Manuel Balce Ceneta, File)

President Barack Obama waves from the top of the steps of Air Force One at Andrews Air Force Base in Md., Tuesday, Jan. 29, 2013. Obama is traveling to Las Vegas to deliver a speech on immigration. (AP Photo/Susan Walsh)

The lights of the U.S. Capitol remain lit into the night on Tuesday, Jan. 1, 2013. In the short term, the economy's headwinds are still restraining growth, including, th heaviest millstone weighing down the economy; the rift between President Barack Obama and Republicans over taxes and spending. (AP Photo/Jacquelyn Martin)

Ben Bernanke's term as chairman of the Federal Reserve expires one year from Thursday. Sometime between now and then he's likely to take his foot off the gas pedal of financial stimulus that is helping to fuel the still-weak U.S. recovery and begin tapping on the brakes.

First appointed by President George W. Bush in 2006 and given a second four-year term as chairman by President Barack Obama, Bernanke hasn't signaled whether he'd like a third term as head of the nation's central bank if Obama pressed him to stay.

But speculation abounds that the former Princeton economics professor is ready to call it quits.

The central bank under Bernanke has kept interest rates ultra-low for more than four years.

At the same time, the Fed has effectively been printing money to buy hundreds of billions of dollars of mortgage-backed and U.S. Treasury securities, further holding down rates and pumping new money into the economy.

Many economists credit such policies for helping to keep the deepest U.S. downturn since the Great Recession from being far worse.

But the chief danger of such easy-money policies is inflation.

It's been tame so far, but at some point it's bound to roar back ? which is why a time will come for Bernanke and fellow Fed members to begin to unwind years of financial stimulus by halting the bond purchases and raising interest rates again.

No one knows just when ? but it probably won't be at the two-day Fed meeting that began in Washington on Tuesday.

Instead, the Fed is expected to push on with its efforts to spur growth so long as economic inflation remains in check and unemployment stays so high.

Janet Yellen, the vice chairman of the Fed, is seen as most likely to be offered the top position by Obama if Bernanke retires.

___

Follow Tom Raum on Twitter: http://www.twitter.com/tomraum

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-01-29-The%20Reset/id-2ff802cc93a945b585413b6403bf7526

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Man wrongly charged in Texas shooting released from jail

SAN ANTONIO (Reuters) - A man who police said was wrongly charged in connection with a shooting at a Texas community college last week, was released from jail on Monday after charges against him were dismissed.

Carlton Berry, 22, who was being treated in a jail hospital ward for injuries he received in the shooting, was released from jail on Monday afternoon, said Sara Kinney, a spokeswoman for the Harris County District Attorney's Office.

"All the charges against him were dismissed," Kinney said. "He is free to go."

No one was killed in the shooting on a campus of Lone Star College near Houston. But the incident raised national concern coming just over a month after the massacre of children at a Newtown, Connecticut, elementary school.

Berry was the first person charged after the January 22 shooting. He was charged with aggravated assault based on an erroneous identification of him as the shooter by a witness.

Police later charged a second person, Trey Foster, 22, in the case. Foster made his first court appearance on Monday. Jail records show he remains behind bars on two felony charges of aggravated assault with a deadly weapon and one count of misdemeanor resisting arrest.

The confrontation started after a third person, Jody Neal, bumped into Foster on the campus, police said. An argument erupted and officials say Foster fired 10 shots. Neal, Berry, who had gone to the library with Foster, and a college maintenance man were wounded.

Investigators originally thought Foster accidentally shot himself but have revised that to indicate that they now believe Foster shot all three men.

Foster was arrested on Friday in the Dallas suburb of Plano, and a gun, believed to be the weapon used in the shooting, was recovered, officials said.

(Reporting by Jim Forsyth; Editing by Greg McCune and Eric Beech)

Source: http://news.yahoo.com/man-wrongly-charged-texas-shooting-released-jail-234217748.html

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Monday, January 28, 2013

Neuroscientists pinpoint location of fear memory in amygdala

Jan. 27, 2013 ? A rustle of undergrowth in the outback: it's a sound that might make an animal or person stop sharply and be still, in the anticipation of a predator. That "freezing" is part of the fear response, a reaction to a stimulus in the environment and part of the brain's determination of whether to be afraid of it.

A neuroscience group at Cold Spring Harbor Laboratory (CSHL) led by Assistant Professor Bo Li Ph.D., together with collaborator Professor Z. Josh Huang Ph.D., have just released the results of a new study that examines the how fear responses are learned, controlled, and memorized. They show that a particular class of neurons in a subdivision of the amygdala plays an active role in these processes.

Locating fear memory in the amygdala

Previous research had indicated that structures inside the amygdalae, a pair of almond-shaped formations that sit deep within the brain and are known to be involved in emotion and reward-based behavior, may be part of the circuit that controls fear learning and memory. In particular, a region called the central amygdala, or CeA, was thought to be a passive relay for the signals relayed within this circuit.

Li's lab became interested when they observed that neurons in a region of the central amygdala called the lateral subdivision, or CeL, "lit up" in a particular strain of mice while studying this circuit.

"Neuroscientists believed that changes in the strength of the connections onto neurons in the central amygdala must occur for fear memory to be encoded," Li says, "but nobody had been able to actually show this."

This led the team to further probe into the role of these neurons in fear responses and furthermore to ask the question: If the central amygdala stores fear memory, how is that memory trace read out and translated into fear responses?

To examine the behavior of mice undergoing a fear test the team first trained them to respond in a Pavlovian manner to an auditory cue. The mice began to "freeze," a very common fear response, whenever they heard one of the sounds they had been trained to fear.

To study the particular neurons involved, and to understand them in relation to the fear-inducing auditory cue, the CSHL team used a variety of methods. One of these involved delivering a gene that encodes for a light-sensitive protein into the particular neurons Li's group wanted to look at.

By implanting a very thin fiber-optic cable directly into the area containing the photosensitive neurons, the team was able to shine colored laser light with pinpoint accuracy onto the cells, and in this manner activate them. This is a technique known as optogenetics. Any changes in the behavior of the mice in response to the laser were then monitored.

A subset of neurons in the central amygdala controls fear expression

The ability to probe genetically defined groups of neurons was vital because there are two sets of neurons important in fear-learning and memory processes. The difference between them, the team learned, was in their release of message-carrying neurotransmitters into the spaces called synapses between neurons. In one subset of neurons, neurotransmitter release was enhanced; in another it was diminished. If measurements had been taken across the total cell population in the central amygdala, neurotransmitter levels from these two distinct sets of neurons would have been averaged out, and thus would not have been detected.

Li's group found that fear conditioning induced experience-dependent changes in the release of neurotransmitters in excitatory synapses that connect with inhibitory neurons -- neurons that suppress the activity of other neurons -- in the central amygdala. These changes in the strength of neuronal connections are known as synaptic plasticity.

Particularly important in this process, the team discovered, were somatostatin-positive (SOM+) neurons. Somatostatin is a hormone that affects neurotransmitter release. Li and colleagues found that fear-memory formation was impaired when they prevent the activation of SOM+ neurons.

SOM+ neurons are necessary for recall of fear memories, the team also found. Indeed, the activity of these neurons alone proved sufficient to drive fear responses. Thus, instead of being a passive relay for the signals driving fear learning and responses in mice, the team's work demonstrates that the central amygdala is an active component, and is driven by input from the lateral amygdala, to which it is connected.

"We find that the fear memory in the central amygdala can modify the circuit in a way that translates into action -- or what we call the fear response," explains Li.

In the future Li's group will try to obtain a better understanding of how these processes may be altered in post-traumatic stress disorder (PTSD) and other disorders involving abnormal fear learning. One important goal is to develop pharmacological interventions for such disorders.

Li says more research is needed, but is hopeful that with the discovery of specific cellular markers and techniques such as optogenetics, a breakthrough can be made.

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Story Source:

The above story is reprinted from materials provided by Cold Spring Harbor Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Haohong Li, Mario A Penzo, Hiroki Taniguchi, Charles D Kopec, Z Josh Huang, Bo Li. Experience-dependent modification of a central amygdala fear circuit. Nature Neuroscience, 2013; DOI: 10.1038/nn.3322

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/lxzF37HaE7w/130128104739.htm

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Primates too can move in unison

Jan. 25, 2013 ? Japanese researchers show for the first time that primates modify their body movements to be in tune with others, just like humans do. Humans unconsciously modify their movements to be in synchrony with their peers. For example, we adapt our pace to walk in step or clap in unison at the end of a concert. This phenomenon is thought to reflect bonding and facilitate human interaction. Researchers from the RIKEN Brain Science Institute report that pairs of macaque monkeys also spontaneously coordinate their movements to reach synchrony.

This research opens the door to much-needed neurophysiological studies of spontaneous synchronization in monkeys, which could shed light into human behavioral dysfunctions such as those observed in patients with autism spectrum disorders, echopraxia and echolalia -- where patients uncontrollably imitate others.

In the research, recently published in the journal Scientific Reports, the team led by Naotaka Fujii developed an experimental set-up to test whether pairs of Japanese macaque monkeys synchronize a simple push-button movement.

Before the experiment, the monkeys were trained to push a button with one hand. In a first experiment the monkeys were paired and placed facing each other and the timing of their push-button movements was recorded. The same experiment was repeated but this time each monkey was shown videos of another monkey pushing a button at varying speeds. And in a last experiment the macaques were not allowed to either see or hear their video-partner.

The results show that the monkeys modified their movements -- increased or decreased the speed of their push-button movement -- to be in synchrony with their partner, both when the partner was real and on video. The speed of the button pressing movement changed to be in harmonic or sub-harmonic synchrony with the partners' speed. However, different pairs of monkeys synchronized differently and reached different speeds, and the monkeys synchronized their movements the most when they could both see and hear their partner.

The researchers note that this behavior cannot have been learnt by the monkeys during the experiment, as previous research has shown that it is extremely difficult for monkeys to learn intentional synchronization.

They add: "The reasons why the monkeys showed behavioral synchronization are not clear. It may be a vital aspect of other socially adaptive behavior, important for survival in the wild."

The study was partly supported by Grant-in-Aid for Scientific Research on Innovative Areas 'Neural creativity for communication' (22120522 and 24120720) of MEXT, Japan.

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The above story is reprinted from materials provided by RIKEN.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Yasuo Nagasaka, Zenas C. Chao, Naomi Hasegawa, Tomonori Notoya, Naotaka Fujii. Spontaneous synchronization of arm motion between Japanese macaques. Scientific Reports, 2013; 3 DOI: 10.1038/srep01151

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/AMbAPs6-r80/130128081952.htm

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'Quantum smell' idea gains ground

The BBC's Jason Palmer visits a perfume store to find out more

A controversial theory that the way we smell involves a quantum physics effect has received a boost, following experiments with human subjects.

It challenges the notion that our sense of smell depends only on the shapes of molecules we sniff in the air.

Instead, it suggests that the molecules' vibrations are responsible.

A way to test it is with two molecules of the same shape, but with different vibrations. A report in PLOS ONE shows that humans can distinguish the two.

Tantalisingly, the idea hints at quantum effects occurring in biological systems - an idea that is itself driving a new field of science, as the BBC feature article Are birds hijacking quantum physics? points out.

But the theory - first put forward by Luca Turin, now of the Fleming Biomedical Research Sciences Centre in Greece - remains contested and divisive.

The idea that molecules' shapes are the only link to their smell is well entrenched, but Dr Turin said there were holes in the idea.

He gave the example of molecules that include sulphur and hydrogen atoms bonded together - they may take a wide range of shapes, but all of them smell of rotten eggs.

"If you look from the [traditional] standpoint... it's really hard to explain," Dr Turin told BBC News.

"If you look from the standpoint of an alternative theory - that what determines the smell of a molecule is the vibrations - the sulphur-hydrogen mystery becomes absolutely clear."

Molecules can be viewed as a collection of atoms on springs, so the atoms can move relative to one another. Energy of just the right frequency - a quantum - can cause the "springs" to vibrate, and in a 1996 paper in Chemical Senses Dr Turin said it was these vibrations that explained smell.

The mechanism, he added, was "inelastic electron tunnelling": in the presence of a specific "smelly" molecule, an electron within a smell receptor in your nose can "jump" - or tunnel - across it and dump a quantum of energy into one of the molecule's bonds - setting the "spring" vibrating.

But the established smell science community has from the start argued that there is little proof of this.

Of horses and unicorns

One way to test the idea was to prepare two molecules of identical shape but with different vibrations - done by replacing a molecule's hydrogen atoms with their heavier cousins called deuterium.

Continue reading the main story

?Start Quote

There are many, many problems with the shape theory of smell - many things it doesn't explain that the vibrational theory does?

End Quote Prof Tim Jacob University of Cardiff

Leslie Vosshall of The Rockefeller University set out in 2004 to disprove Dr Turin's idea with a molecule called acetophenone and its "deuterated" twin.

The work in Nature Neuroscience suggested that human participants could not distinguish between the two, and thus that vibrations played no role in what we smell.

But in 2011, Dr Turin and colleagues published a paper in Proceedings of the National Academy of Sciences showing that fruit flies can distinguish between the heavier and lighter versions of the same molecule.

A repeat of the test with humans in the new paper finds that, as in Prof Vosshall's work, the subjects could not tell the two apart. But the team then developed a brand new, far larger pair of molecules - cyclopentadecanone - with more hydrogen or deuterium bonds to amplify the purported effect.

In double-blind tests, in which neither the experimenter nor the participant knew which sample was which, subjects were able to distinguish between the two versions.

Still, Prof Vosshall believes the vibrational theory to be no more than fanciful.

"I like to think of the vibration theory of olfaction and its proponents as unicorns. The rest of us studying olfaction are horses," she told BBC News.

"The problem is that proving that a unicorn exists or does not exist is impossible. This debate on the vibration theory or the existence of unicorns will never end, but the very important underlying question of why things smell the way they do will continue to be answered by the horses among us."

Tim Jacob, a smell researcher at the University of Cardiff, said the work was "supportive but not conclusive".

"But the fact is that nobody has been able to unequivocally contradict [Dr Turin]," he told BBC News.

"There are many, many problems with the shape theory of smell - many things it doesn't explain that the vibrational theory does."

And although many more scientists are taking the vibrational theory seriously than back in 1996, it remains an extraordinarily polarised debate.

"He's had some peripheral support, but... people don't want to line up behind Luca," Prof Jacob said. "It's scientific suicide."

Columbia University's Richard Axel, whose work on mapping the genes and receptors of our sense of smell garnered the 2004 Nobel prize for physiology, said the kinds of experiments revealed this week would not resolve the debate - only a microscopic look at the receptors in the nose would finally show what is at work.

"Until somebody really sits down and seriously addresses the mechanism and not inferences from the mechanism... it doesn't seem a useful endeavour to use behavioural responses as an argument," he told BBC News.

"Don't get me wrong, I'm not writing off this theory, but I need data and it hasn't been presented."

Source: http://www.bbc.co.uk/news/science-environment-21150046#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Sunday, January 27, 2013

The Great Profecy on the planet Koroth...

The Great Profecy on the planet Koroth...

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2-D electronic devices, may be possible: Fine patterns made with single-atom-thick graphene and boron nitride

Jan. 27, 2013 ? Rice University scientists have taken an important step toward the creation of two-dimensional electronics with a process to make patterns in atom-thick layers that combine a conductor and an insulator.

The materials at play -- graphene and hexagonal boron nitride -- have been merged into sheets and built into a variety of patterns at nanoscale dimensions.

Rice introduced a technique to stitch the identically structured materials together nearly three years ago. Since then, the idea has received a lot of attention from researchers interested in the prospect of building 2-D, atomic-layer circuits, said Rice materials scientist Pulickel Ajayan. He is one of the authors of the new work that appears this week in Nature Nanotechnology. In particular, Ajayan noted that Cornell University scientists reported an advance late last year on the art of making atomic-layer heterostructures through sequential growth schemes.

This week's contribution by Rice offers manufacturers the possibility of shrinking electronic devices into even smaller packages. While Rice's technical capabilities limited features to a resolution of about 100 nanometers, the only real limits are those defined by modern lithographic techniques, according to the researchers. (A nanometer is one-billionth of a meter.)

"It should be possible to make fully functional devices with circuits 30, even 20 nanometers wide, all in two dimensions," said Rice researcher Jun Lou, a co-author of the new paper. That would make circuits on about the same scale as in current semiconductor fabrication, he said.

Graphene has been touted as a wonder material since its discovery in the last decade. Even at one atom thick, the hexagonal array of carbon atoms has proven its potential as a fascinating electronic material. But to build a working device, conductors alone will not do. Graphene-based electronics require similar, compatible 2-D materials for other components, and researchers have found hexagonal boron nitride (h-BN) works nicely as an insulator.

H-BN looks like graphene, with the same chicken-wire atomic array. The earlier work at Rice showed that merging graphene and h-BN via chemical vapor deposition (CVD) created sheets with pools of the two that afforded some control of the material's electronic properties. Ajayan said at the time that the creation offered "a great playground for materials scientists."

He has since concluded that the area of two-dimensional materials beyond graphene "has grown significantly and will play out as one of the key exciting materials in the near future."

His prediction bears fruit in the new work, in which finely detailed patterns of graphene are laced into gaps created in sheets of h-BN. Combs, bars, concentric rings and even microscopic Rice Owls were laid down through a lithographic process. The interface between elements, seen clearly in scanning transmission electron microscope images taken at Oak Ridge National Laboratories, shows a razor-sharp transition from graphene to h-BN along a subnanometer line.

"This is not a simple quilt," Lou said. "It's very precisely engineered. We can control the domain sizes and the domain shapes, both of which are necessary to make electronic devices."

The new technique also began with CVD. Lead author Zheng Liu, a Rice research scientist, and his colleagues first laid down a sheet of h-BN. Laser-cut photoresistant masks were placed over the h-BN, and exposed material was etched away with argon gas. (A focused ion beam system was later used to create even finer patterns, down to 100-nanometer resolution, without masks.) After the masks were washed away, graphene was grown via CVD in the open spaces, where it bonded edge-to-edge with the h-BN. The hybrid layer could then be picked up and placed on any substrate.

While there's much work ahead to characterize the atomic bonds where graphene and h-BN domains meet and to analyze potential defects along the boundaries, Liu's electrical measurements proved the components' qualities remain intact.

"One important thing Zheng showed is that even by doing all kinds of growth, then etching, then regrowth, the intrinsic properties of these two materials are not affected," Lou said. "Insulators stay insulators; they're not doped by the carbon. And the graphene still looks very good. That's important, because we want to be sure what we're growing is exactly what we want."

Liu said the next step is to place a third element, a semiconductor, into the 2-D fabric. "We're trying very hard to integrate this into the platform," he said. "If we can do that, we can build truly integrated in-plane devices." That would give new options to manufacturers toying with the idea of flexible electronics, he said.

"The contribution of this paper is to demonstrate the general process," Lou added. "It's robust, it's repeatable and it creates materials with very nice properties and with dimensions that are at the limit of what is possible."

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The above story is reprinted from materials provided by Rice University, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. C. Drexler, S. A. Tarasenko, P. Olbrich, J. Karch, M. Hirmer, F. M?ller, M. Gmitra, J. Fabian, R. Yakimova, S. Lara-Avila, S. Kubatkin, M. Wang, R. Vajtai, P. M. Ajayan, J. Kono, S. D. Ganichev. Magnetic quantum ratchet effect in graphene. Nature Nanotechnology, 2013; DOI: 10.1038/nnano.2012.231

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/Z5aTSo83LOQ/130127134208.htm

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Smartphone pioneer RIM looks to put recent hardships behind it with BB10

TORONTO, Cananda - Once a leader but now derided as a laggard, BlackBerry-maker Research In Motion hopes to regain the confidence of cynical smartphone users this week as the curtain is lifted on its much-anticipated new smartphones.

The stakes are high for the unveiling, which many observers say will determine whether RIM survives to see the launch of another BlackBerry smartphone.

It has been a steep decline for RIM, which less than five years ago was the most valuable company in Canada, above Royal Bank (TSX:RY). Affectionately called the "CrackBerry" maker, the mobile communications pioneer was Canada's crowning achievement of the technology sector.

Back in 1984, the year RIM was founded, it was practically unimaginable that a tiny startup based in Waterloo, Ont. would help change the way we communicate, but for fresh engineering graduates Mike Lazaridis and Douglas Fregin that was always the plan.

"Like so many of these guys Lazaridis was a Star Trek lunatic," said Alastair Sweeny, author of "BlackBerry Planet."

"He says it's almost like telepathy ? humans have a yearning to communicate."

The beginnings were humble for the two founders, with the majority of their time dedicated to Budgie, an LED sign business that was contracted by General Motors to communicate messages to workers on its assembly lines. Despite early interest, the project was a sales flop and RIM's owners decided to sell the business and look at other ventures.

One of those projects put RIM squarely in the eyes of Hollywood. The DigiSync film reader caught on with movie editors because its synching technology shaved hours off the time it took to turn miles of film into useable content in post-production. While the technology went on to win RIM both an Emmy and a technical achievement from the Academy Awards, it was never a top priority for RIM's founders.

"Lazaridis was always into security," said Sweeny. "He realized that corporations needed secure communications because of industrial espionage, because of hacking."

Throughout the late 1980s, RIM was working alongside other industry players to develop technology that would eventually be used in pagers and wireless payment processing systems. By the start of the 1990s, the wheels were turning on the communication systems that would become the foundation of the BlackBerry.

An agreement with Ericcson's Mobitex wireless network allowed RIM to create pagers that operated as a two-way communicators, a revolutionary concept for data transfer.

Turning the idea into a marketable product was a bigger challenge. The world had yet to become accustomed to the Internet age and most people hadn't heard of email, nevermind used it. While the project was a bust with its first partner Cantel, RIM forged ahead.

The technology captured the attention and imaginations of an industry, and perhaps most importantly Jim Balsillie, an energetic Harvard graduate who, at the age of 33, invested $250,000 of his own money into the company by re-mortgaging his house.

In 1996, RIM launched its first sales success, a clamshell wireless handheld device called the RIM 900 Interactive Pager. It was a two-way communicator that also had the ability to send faxes, as well as link to the Internet and email.

But Lazaridis discovered that the email feature, which he believed was one of the strongest qualities of the device, wasn't being used by most customers. So he hired Lexicon Branding, based in California, to find a way to draw more attention to its keyboard, the main feature that differentiated it from other pagers.

Branding executives pondered the device, focusing mainly on its appearance, and when one of them pointed out the little keypad looked like similar to the seeds of a strawberry, the conversation zeroed in on the names of fruits and vegetables. Eventually, the group settled on "BlackBerry" because it was both punchy and remained true to the device's original black casing.

The company listed on the Toronto Stock Exchange in 1997, raising more than $115 million, and debuted the first BlackBerry the following year.

From there it seemed the sky was the limit.

Suddenly the BlackBerry was everywhere in the technology community, thrust into the spotlight by the enthusiastic co-CEO Balsillie who touted the device on Wall Street and handed it out for free at select technology conferences. Balsillie knew how to build buzz and proudly tapped away on the BlackBerry whenever he appeared before the media.

A demand had been created, and subscribers to the BlackBerry services continued to grow in leaps and bounds. In 1999, RIM listed on the Nasdaq, raising another US$250 million.

The success grabbed the attention of Virginia-based NTP Inc. which filed a lawsuit claiming that RIM's network infringed on its patents. While NTP won the case, and the courts ordered RIM to pay US$23.1 million, the battle continued in appeals courts for years before a settlement was reached for a much heftier $612.5 million.

Outside the courtrooms the BlackBerry was a massive success, garnering headlines when its enterprise network remained intact after the terrorist attacks on Sept. 11 when other wireless phone systems broke down.

The BlackBerry's reputation was growing at a steady clip, helped by the introduction of cellphone service in 2002 on what had been a text-only device. Within two years, BlackBerry reached more than 1 million subscribers.

The smartphone was in demand at corporate offices around the world, and soon the more casual consumer began to take notice, helping to boost its subscribers to nine million by 2007. RIM also secured a distribution deal in China, driving its stock to a level that made it the most valuable Canadian company.

But amid all of the success a storm of competition was brewing in the tech industry.

In June 2007, Apple unleashed the first iPhone touchscreen device onto the U.S. market, garnering widespread praise from critics and consumers, but hardly rattling its competitors.

Microsoft's chief executive Steve Ballmer famously dismissed the touchscreen device that year, saying "there's no chance that the iPhone is going to get any significant market share."

Whether it was a strategic decision or simply coincidence, Apple kept its iPhone far away from the Canadian marketplace for nearly a year, choosing to launch in six other countries first.

The lower profile with Canadian consumers also seemed to minimize the concern from RIM's executives, who publicly downplayed the influence of the iPhone in an already crowded mobile phone market.

"They just missed it," said Carl Howe, vice-president of consumer research at Yankee Group.

"They missed the idea that you could create a really good experience without having a keyboard. They gave Apple a two-year head start."

By the time the iPhone hit Canadian shelves, RIM was facing scrutiny from analysts who worried that the growing number competitors, which now also included Google's Android system, would devour marketshare.

RIM went on the defensive in 2008, releasing a combination keypad and touchscreen device it called the Storm, but the phone was swept up in a flurry of other BlackBerry releases that year. Much of the marketing clout was put behind the debut of a high-end BlackBerry Bold, which wasn't a touchscreen.

"A lot of tech companies have their heads in the sand," said Howe of the co-CEOs.

"It's not that they're stupid, and I think that's an important point. People who get hit by 'innovator's dilemma' are not stupid ... I think when you create something from scratch and turn it into a multi-billion dollar business you're very reluctant to say 'I'm now going to throw away everything I've learned and do something different.' "

At the height of its hype, the BlackBerry device was splashed across television shows and movies, while then-presidential candidate Barack Obama proclaimed he was a BlackBerry faithful during his campaign.

As competition heated up with Apple, investors became concerned that RIM's co-CEOs, in particular Balsillie, were distracted by the possibilities that success brought them, rather than focused on revamping the BlackBerry for a new era.

In 2009, Balsillie launched his third, and most aggressive, attempt to buy an National Hockey League team, with hopes that he could convince the NHL to move the Phoenix Coyotes to Hamilton. The battle dragged on for months before Balsillie abandoned his dream once again.

Back in Waterloo a storm was brewing as technical problems began to wreak havoc on the company's network infrastructure.

There were two network outages in less than a year that left BlackBerry users temporarily without their services. Some industry observers suggested the company could buckle under its own success. BlackBerry sales were soaring, even with the technical problems, with subscriber growth up 70 per cent to 36 million by the end of 2009. RIM's leaders reassured users that the outages were a fluke and wouldn't be a reoccurring problem.

Despite the setbacks, the BlackBerry image appeared to emerge unscathed. In April 2010 it cracked the Top Five mobile phone carriers worldwide and soon afterwards Queen Elizabeth made a visit to RIM's headquarters in Waterloo.

Behind the scenes there was unrest among the company's board of directors as the leaders clashed over where the BlackBerry brand should go next. Rumours swirled around the industry that trouble was afoot.

Fanfare eventually gave way to the realities of competition, with the first major blow coming from the failed launch of the PlayBook, RIM's answer to Apple's iPad. In September 2010, the co-CEOs showcased the new product for the public but waited another six months before unleashing it to stores.

By then it was too late, the tablet market had already been cornered by Apple and reviews of the PlayBook harshly criticized its lack of connectivity to popular BlackBerry functions like email and instant messenger.

Within months the foundation of RIM started to crumble as it repeatedly missed its own revenue and earnings targets. In June 2011, the company slashed 11 per cent of its workforce, or 2,000 jobs, to keep its cost in line.

A stark reminder of its fragility came in October 2011 when a worldwide four-day outage left BlackBerry users again without the use of the device they had come to rely on. The smartphones wouldn't connect to the Internet, email or its messaging services.

The anger from its loyal users was heard loud and clear, and Lazaridis emerged from days of silence to apologize and tell users the company had let them down.

In an earnings call several weeks later, Lazaridis urged investor "patience and confidence" as the executives tried to improve performance. Both he and Balsillie, two of the company's biggest shareholders, reduced their salaries to $1.

Again, it was a decision made too late ? the outage had cost RIM more than $50 million in revenue and tarnished its reputation. In December 2011, the company reported that profits tumbled more than 70 per cent, affected by a big charge from sales discounts it was forced make on PlayBook tablets.

Perhaps an even bigger blow to RIM's reputation was the delay of its next-generation BlackBerrys, pushing the planned release into 2012. The phones ? which were delayed again throughout last year and will be unveiled this Wednesday ? were seen as the company's best hope to maintain market share against Apple and Android devices.

The company stock had tumbled from its lofty height of $137.41 on the Toronto Stock Exchange in mid-2008 to $14.80 at the end of 2011.

RIM, once a symbol of Canadian success and innovation, had become awash in its own troubles. Apple's iPhone had cornered the rapidly developing apps market while RIM sat on the sidelines with developers.

Sweeny recalls visiting a group of developers, who he considered BlackBerry fanatics, while doing research for his book in 2008.

"They were writing great games and programs for the BlackBerry and they couldn't get the latest hardware from RIM to test them on," he said.

"I called them a couple years later and they weren't writing for BlackBerry at all. They were writing programs for Apple and starting to write for Android."

From an outsider's perspective, it's often suggested that the co-CEOs lost control of their empire, but some industry watchers say that RIM saw the troubles several years earlier.

"In this market you can't admit that you're behind," said Tim Long, an analyst at BMO Capital Markets.

"You have to put on the face because once you start to lose momentum that can shift the buying patterns."

Numerous acquisitions were made by RIM throughout 2010 and 2011 to beef up its stable of technology, Long said. That included Ottawa-based QNX Software Systems, whose technology became the basis of the new operating system, and Astonishing Tribe, the Swedish company that helped develop an early user interface of the Android operating system.

But the acquisitions came too late, and by late 2011 some investors were calling for its leaders to resign.

Bowing to pressure, Balsillie and Lazaridis stepped down from their co-CEO positions in January 2012, pocketing a combined $12 million in the process. The duo were replaced by Thorsten Heins, RIM's former chief operating officer, and hardly two months later Balsillie had left the company entirely.

Almost immediately, Heins launched a major revamp of RIM's operations, hiring several new executives with experience at other major tech companies. The approach was a last-ditch effort to revive the company, but it has also thrown the BlackBerry maker into the most uncertain period in its history.

With nearly $2 billion in its coffers Heins had options, but the clock was ticking to get a new smartphone on the market.

"Nobody is delusional here," Rick Costanzo, the company's new executive vice-president of global sales, said last summer.

"We get it. That's why we're building BlackBerry 10 and man are we committed."

A new chapter in RIM's history begins this week as the BlackBerry 10 smartphones and operating system are showcased to the world.

Source: http://news.yahoo.com/smartphone-pioneer-rim-looks-put-recent-hardships-behind-171635399.html

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